US President Donald Trump has stirred controversy after suggesting a link between Tylenol use during pregnancy and autism, a claim strongly disputed by medical experts. Speaking at a White House event on September 22, Trump warned against the popular painkiller and also highlighted ‘leucovorin’, a form of folate, as a possible treatment for autism-related symptoms.
Trump’s Claim on Tylenol and Autism
Trump stated that women should limit acetaminophen (the active ingredient in Tylenol) during pregnancy unless medically necessary. He further claimed that the US Food and Drug Administration (FDA) would soon issue notifications to doctors about the potential risks, though no supporting scientific evidence was presented.
Tylenol, manufactured by Kenvue (a company spun off from Johnson & Johnson in 2023), is one of the most widely used over-the-counter pain relievers. Generic acetaminophen is also commonly available across pharmacies.
FDA Approval of Leucovorin
Trump also spotlighted leucovorin, a form of folinic acid related to folic acid (vitamin B9), which is sometimes used in autism therapy. The FDA recently approved a GSK-made version of leucovorin for treating cerebral folate deficiency, a rare metabolic disorder that can present neurological symptoms similar to those observed in autism.
Medical experts have also expressed concern. Numerous studies have examined the possible relationship between acetaminophen use during pregnancy and autism risk, but findings remain inconclusive. Some research suggests a potential association, while others find no link at all. Experts stress that autism spectrum disorders (ASD) are complex and influenced by both genetic and environmental factors, making it unlikely that a single cause such as Tylenol could be responsible.
According to the World Health Organization (WHO), autism spectrum disorders encompass a range of conditions characterized by challenges in communication, social interaction, and repetitive behaviors. Until the 1990s, autism diagnoses were often limited to children with severe symptoms, but recognition has since broadened.
In 2021, WHO estimated that around 1 in 127 people globally were affected by autism, though prevalence varies by study and region. Rising rates are partly attributed to increased awareness and improved diagnostic practices.
What is Leucovorin?
Leucovorin, also called folinic acid, is a form of vitamin B9 used to reduce the toxic effects of chemotherapy drugs like methotrexate. Some families and practitioners already use it off-label in hopes of improving autism symptoms, although large-scale clinical trials are lacking. Trump’s mention of leucovorin reflects growing public interest in alternative and adjunct therapies, but experts caution against viewing it as a cure.
Key Takeaways
- Trump’s remarks on Tylenol and autism have sparked debate, with experts warning against drawing conclusions without scientific proof.
- Leucovorin may benefit some neurological conditions, but its role in autism treatment is still being studied.
- Autism remains a complex condition shaped by genetics, environment, and multiple biological pathways, not a single drug exposure.
While President Trump’s comments have reignited discussion about autism causes and treatments, health authorities emphasize the importance of evidence-based guidance. Pregnant women should consult their doctors before taking any medication, including Tylenol, and families should approach potential autism therapies with caution until more rigorous research is available.
Helene Elliott is the senior reporter for News Raise. She covers Science news. She also has a keen interest in photojournalism. Helene holds a nomination for the prestigious Red Smith Award. She is married to author Dennis D’Agostino, a former publicist with the New York Mets.
